A free radical spin trap
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EMPO

Item No. 20618

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dihydro-2-methyl-2H-pyrrole-2-carboxylic acid 1-oxide, ethyl ester
CAS Number
61856-99-3
Synonyms
  • 5-(Ethoxycarbonyl)-5-methyl-1-Pyrroline-N-Oxide
Molecular Formula
C8H13NO3
Formula Weight
171.2
Purity
≥95%
Formulation (Request formulation change)
A 25 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 15 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
238 nm
SMILES
[O-][N+]1=CCCC1(C)C(OCC)=O
InChi Code
InChI=1S/C8H13NO3/c1-3-12-7(10)8(2)5-4-6-9(8)11/h6H,3-5H2,1-2H3
InChi Key
IIPNDONTVPDUFZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

    $93

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    25 mg

    $190

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    50 mg

    $329

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    Product Description

    EMPO is a hydrophilic cyclic nitrone analog of the free radical spin trap DMPO (Item No. 10006436). The EMPO-superoxide adduct (EMPO-OOH) exhibits an ESR spectrum that is similar to the DMPO-OOH spectrum.1 However, the EMPO-OOH adduct is about 5-8 times more stable (t1/2 = 4.8 – 8.6 min) and does not spontaneously decay to the hydroxyl adduct, making spectral interpretation less difficult.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Olive, G., Mercier, A., Le Moigne, F., et al. 2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide: evaluation of the spin trapping properties. Free Radic. Biol. Med. 28(3), 403-408 (2000).

    2. Stolze, K., Udilova, N., and Nohl, H. Spin adducts of superoxide, alkoxyl, and lipid-derived radicals with EMPO and its derivatives. Biol. Chem. 383(5), 813-820 (2002).

    3. Zhang, H., Joseph, J., Vasquez-Vivar, J., et al. Detection of superoxide anion using an isotopically labeled nitrone spin trap: Potential biological applications. FEBS Lett. 473(1), 58-62 (2000).