A SHP-1(ΔSH2) inhibitor
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PTP Inhibitor II

Item No. 20629

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-bromo-1-(4-methoxyphenyl)-ethanone
CAS Number
2632-13-5
Synonyms
  • α-Bromo-4’-methoxyacetophenone
  • ω-Bromo-4’-methoxyacetophenone
  • 4-(Bromoacetyl)anisole
  • 4-Methoxyphenacyl bromide
  • NSC 129010
  • Protein Tyrosine Phosphatase Inhibitor II
Molecular Formula
C9H9BrO2
Formula Weight
229.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlEthanol:PBS (pH 7.2) (1:10): 0.09 mg/ml
λmax
222, 285 nm
SMILES
COC1=CC=C(C(CBr)=O)C=C1
InChi Code
InChI=1S/C9H9BrO2/c1-12-8-4-2-7(3-5-8)9(11)6-10/h2-5H,6H2,1H3
InChi Key
XQJAHBHCLXUGEP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $36

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    25 g

    $77

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    50 g

    $135

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    100 g

    $236

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    Product Description

    PTP inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)).1 PTP inhibitor II binds with lower affinity than PTP Inhibitor I (Item No. 19766) with Ki values of 128 and 43 μM, respectively.1 SHP-1 has known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Arabaci, G., Guo, X.-C., Beebe, K.D., et al. α-Haloacetophenone derivatives as photoreversible covalent inhibitors of protein tyrosine phosphatases. J. Am. Chem. Soc. 121(21), 5085-5086 (1999).

    2. Heneberg, P. Use of protein tyrosine phosphatase inhibitors as promising targeted therapeutic drugs. Curr. Med. Chem. 16(6), 706-733 (2009).