A riboflavin analog
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Lumiflavine

Item No. 20645

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7,8,10-trimethyl-benzo[g]pteridine-2,4(3H,10H)-dione
CAS Number
1088-56-8
Molecular Formula
C13H12N4O2
Formula Weight
256.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
λmax
221, 267, 348, 441 nm
SMILES
CC(C(C)=C1)=CC2=C1N(C)C(C3=N2)=NC(NC3=O)=O
InChi Code
InChI=1S/C13H12N4O2/c1-6-4-8-9(5-7(6)2)17(3)11-10(14-8)12(18)16-13(19)15-11/h4-5H,1-3H3,(H,16,18,19)
InChi Key
KPDQZGKJTJRBGU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $44

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    10 mg

    $84

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    25 mg

    $161

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    50 mg

    $302

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    Product Description

    Lumiflavine is a structural analog of the water-soluble vitamin riboflavin that has been used to study the mechanism of uptake of riboflavin into intestinal epithelial (Caco-2) and human retinal pigment epithelial (hRPE) cells.1,2 It inhibits the uptake of radiolabeled riboflavin approximately 3-fold (at 25 µM) and 30-fold (at 10 µM) in Caco-2 cells and hRPE cells, respectively.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Said, H.M., and Ma, T.Y. Mechanism of riboflavine uptake by Caco-2 human intestinal epithelial cells. Am. J. Physiol. 266( 1 pt 1), G15-G21 (1994).

    2. Said, H.M., Wang, S., and Ma, T.Y. Mechanism of riboflavin uptake by cultured human retinal pigment epithelial ARPE-19 cells: Possible regulation by an intracellular Ca2+-calmodulin-mediated pathway. J. Physiol. 556 (Pt 2), 369-377 (2005).