A homobifunctional crosslinking agent
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Product Type

Biochemicals

Research Area

Disuccinimidyl Glutarate

Item No. 20646

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
pentanedioic acid, 1,5-bis(2,5-dioxo-1-pyrrolidinyl) ester
CAS Number
79642-50-5
Synonyms
  • DSG
Molecular Formula
C13H14N2O8
Formula Weight
326.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2)(1:5): 0.15 mg/ml
SMILES
O=C(CCCC(ON(C(CC1)=O)C1=O)=O)ON2C(CCC2=O)=O
InChi Code
InChI=1S/C13H14N2O8/c16-8-4-5-9(17)14(8)22-12(20)2-1-3-13(21)23-15-10(18)6-7-11(15)19/h1-7H2
InChi Key
LNQHREYHFRFJAU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $36

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    10 mg

    $68

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    25 mg

    $145

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    50 mg

    $268

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    Product Description

    Disuccinimidyl glutarate (DSG) is a homobifunctional crosslinking agent that contains amine-reactive N-hydroxysuccinimide (NHS) ester groups at each end.1,2 DSG is membrane-permeable and non-cleavable. DSG can be combined with formaldehyde fixation to improve the detection of specific protein-DNA complexes.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Akin, B.L., and Jones, L.R. Characterizing phospholamban to sarco(endo)plasmic reticulum Ca2+-ATPase 2a (SERCA2a) protein binding interactions in human cardiac sarcoplasmic reticulum vesicles using chemical cross-linking. The Journal of Biological Chemisty 287(10), 7582-7593 (2012).

    2. Huang, B.X., Kim, H.-Y., and Dass, C. Probing three-dimensional structure of bovine serum albumin by chemical cross-linking and mass spectrometry. J. Am. Soc. Mass Spectrom. 15, 1237-1247 (2004).

    3. Aoki, T., Wolle, D., Preger-Ben Noon, E., et al. Bi-functional cross-linking reagents efficiently capture protein-DNA complexes in Drosophila embryos. Fly 8(1), 43-51 (2014).