A creatine analog
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals

Research Area

Neuroscience
Behavioral Neuroscience
Learning & Memory

Cyclocreatine

Item No. 20649

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-4,5-dihydro-1H-imidazole-1-acetic acid
CAS Number
35404-50-3
Synonyms
  • AM 285
  • 1-Carboxymethyl-2-iminoimidazolidine
Molecular Formula
C5H9N3O2
Formula Weight
143.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 2 mg/mL
SMILES
NC1=NCCN1CC(O)=O
InChi Code
InChI=1S/C5H9N3O2/c6-5-7-1-2-8(5)3-4(9)10/h1-3H2,(H2,6,7)(H,9,10)
InChi Key
AMHZIUVRYRVYBA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 mg

    $54

    Add

    1 g

    $85

    Add

    5 g

    $392

    Add

    10 g

    $627

    Add
    Product Description

    Cyclocreatine is a planar creatine analog that can passively transit across membranes, including the blood brain barrier, and is phosphorylated and dephosphoryated by mitochondrial and cytosolic creatine kinase.1,2 Cyclocreatine can function as a phosphagen in mouse brain in vivo and has been used to reverse cognitive deficits in Slc6a8-/y mice that lack a functional creatine transporter.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McLaughlin, A.C., and Cohn, M. Specificity of creatine kinase for guanidino substrates. Kinetic and proton nuclear magnetic relaxation rate studies. The Journal of Biological Chemisty 247(13), 4382-4388 (1972).

    2. Boehm, E.A., Radda, G.K., Tomlin, H., et al. The utilisation of creatine and its analogues by cytosolic and mitochondrial creatine kinase. Biochim. Biophys. Acta 1274(3), 119-128 (1996).

    3. Kurosawa, Y., DeGrauw, T.J., Lindquist, D.M., et al. Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency. J. Clin. Invest. 122(8), 2837-2846 (2012).