A serine protease inhibitor
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Benzamidine (hydrochloride)

Item No. 20651

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
benzenecarboximidamide, monohydrochloride
CAS Number
1670-14-0
Molecular Formula
C7H8N2 • HCl
Formula Weight
156.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 3 mg/ml
λmax
229 nm
SMILES
NC(C1=CC=CC=C1)=N.Cl
InChi Code
InChI=1S/C7H8N2.ClH/c8-7(9)6-4-2-1-3-5-6;/h1-5H,(H3,8,9);1H
InChi Key
LZCZIHQBSCVGRD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $42

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    10 g

    $70

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    25 g

    $103

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    100 g

    $242

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    Product Description

    Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 µM, respectively).1,2,3 In addition to its use as a general serine protease inhibitor, benzamidine is used, when immobilized, to purify novel proteases.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, Y., Liu, M., and Hilty, C. Parallelized ligand screening using dissolution dynamic nuclear polarization. Anal. Chem. 88(22), 11178-11183 (2016).

    2. Markwardt, F., Landmann, H., and Walsmann, P. Comparative studies on the inhibition of trypsin, plasmin, and thrombin by derivatives of benzylamine and benzamidine. Eur. J. Biochem. 6(4), 502-506 (1968).

    3. Saldívar-Hernández, A., González-González, M.E., Sánchez-Tusié, A., et al. Human sperm degradation of zona pellucida proteins contributes to fertilization. Reprod. Biol. Endocrinol. 13, 99 (2015).

    4. Matsuura, Y., Yabu, T., Shiba, H., et al. Purification and characterization of a fish granzymeA involved in cell-mediated immunity. Dev. Comp. Immunol. 60, 33-40 (2016).

    5. Staffansson, B., Sandholt, G.B., and Gudmundsdottir, Á. Elucidation of different cold-adapted Atlantic cod (Gadus morhua) trypsin X isoenzymes. Biochim. Biophys. Acta 1865(1), 11-19 (2017).