A COX-2 inhibitor
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Feprazone

Item No. 20652

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(3-methyl-2-buten-1-yl)-1,2-diphenyl-3,5-pyrazolidinedione
CAS Number
30748-29-9
Molecular Formula
C20H20N2O2
Formula Weight
320.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 0.5 mg/mlWater: 1 mg/ml
λmax
240 nm
SMILES
O=C1C(C/C=C(C)/C)C(N(C2=CC=CC=C2)N1C3=CC=CC=C3)=O
InChi Code
InChI=1S/C20H20N2O2/c1-15(2)13-14-18-19(23)21(16-9-5-3-6-10-16)22(20(18)24)17-11-7-4-8-12-17/h3-13,18H,14H2,1-2H3
InChi Key
RBBWCVQDXDFISW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 mg

    $54

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    50 mg

    $102

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    100 mg

    $190

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    Product Description

    Feprazone is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor that is 10-fold selective for COX-2 over COX-1.1 It reduces LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production in bovine arterial endothelial cells (IC50 = 1 μM). Oral administration of feprazone (25-100 mg/kg) reduces vascular permeability, edema, and nociception in a rat model of adjuvant-induced arthritis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hou, Q., Hu, Y., Guo, Y., et al. Effects of feprazone on cyclooxygenase in vitro. Yaoxue Xuebao 35(7), 481-483 (2000).

    2. Tsurumi, K., Kyuki, K., Togawa, Y., et al. Pharmacological studies of 4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione (Feprazone DA-2370). 1. Anti-inflammatory, analgesic and antipyretic properties. Oyo Yakuri 16(3), 413-429 (1978).