A Dkk1 inhibitor
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Gallocyanine

Item No. 20657

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-carboxy-7-(dimethylamino)-3,4-dihydroxy-phenoxazin-5-ium, monochloride
CAS Number
1562-85-2
Synonyms
  • IIIC3
  • Alizarine Navy Blue
  • Anthracene Blue SWGG
  • Brilliant Chrome Blue P
  • C.I. 51030
  • Fast Violet
  • Mordant Blue 10
Molecular Formula
C15H13N2O5 • Cl
Formula Weight
336.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
314, 399, 600, 607 nm
SMILES
OC(C1=CC(O)=C(O)C2=[O+]C3=CC(N(C)C)=CC=C3N=C21)=O.[Cl-]
InChi Code
InChI=1S/C15H12N2O5.ClH/c1-17(2)7-3-4-9-11(5-7)22-14-12(16-9)8(15(20)21)6-10(18)13(14)19;/h3-6H,1-2H3,(H2-,16,18,19,20,21);1H
InChi Key
ADAUKUOAOMLVSN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $42

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    25 g

    $97

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    Product Description

    Gallocyanine is a small molecule blue dye used to stain nuclei. It is known to inhibit Dickkopf-1 (Dkk1), an antagonist of the Wnt pathway. Gallocyanine can disrupt the interaction of Dkk1 with its receptor LRP5/6 (IC50 = 3 µM), thereby activating Wnt/β-catenin signaling.1 Modulation of the Dkk1-LRP5/6 interaction via gallocyanine has been shown to inhibit prostaglandin J2-induced tau phosphorylation at serine396 in primary cortical neurons in vitro.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mpousis, S., Thysiadis, S., Avramidis, N., et al. Synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of Alzheimer’s disease and related neurodegenerative tauopathies. Eur. J. Med. Chem. 108, 28-38 (2016).