A natural antibiotic
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Resistomycin

Item No. 20685

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5,7,10-tetrahydroxy-1,1,9-trimethyl-2H-benzo[cf]pyrene-2,6(1H)-dione
CAS Number
20004-62-0
Synonyms
  • Antibiotic A-3733A
  • Heliomycin
Molecular Formula
C22H16O6
Formula Weight
376.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: Soluble
SMILES
O=C1C(C)(C)C2=C3C4=C(C(O)=CC(C)=C4C(O)=C2)C(C5=C(O)C=C(O)C1=C53)=O
InChi Code
InChI=1S/C22H16O6/c1-7-4-9(23)15-18-13(7)10(24)5-8-14(18)19-16(20(15)27)11(25)6-12(26)17(19)21(28)22(8,2)3/h4-6,23-26H,1-3H3
InChi Key
ABLACSIRCKEUOB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $202

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    5 mg

    $699

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    Cayman Chemical
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    Product Description

    Resistomycin is a natural antibiotic produced by several actinobacteriae, including Streptomyces. Resistomycin, as well as culture broths rich in resistomycin, have antioxidant activity, modulate apoptosis, and can be cytotoxic against cancer cell lines.1,2 Resistomycin also has activity against HIV-1 protease.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shiono, Y., Shiono, N., Seo, S., et al. Effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia CMK-7 cell line. Z. Naturforsch. C. 57(9-10), 923-929 (2002).

    2. Vijayabharathi, R., Bruheim, P., Andreassen, T., et al. Assessment of resistomycin, as an anticancer compound isolated and characterized from Streptomyces aurantiacus AAA5. J. Microbiol. 49(6), 920-926 (2011).

    3. Roggo, B.E., Petersen, F., Delmendo, R., et al. 3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin: New inhibitors of HIV-1 protease. I. Fermentation, isolation and biological activity. J. Antibiot. (Tokyo) 47(2), 136-142 (1994).