A β2-AR agonist
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Vilanterol

Item No. 20702

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α1R-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol
CAS Number
503068-34-6
Synonyms
  • GSK642444
  • GW 642444
Molecular Formula
C24H33Cl2NO5
Formula Weight
486.4
Purity
≥98%
Formulation
A 5 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 10 mg/mlEthanol: 30 mg/ml
SMILES
ClC1=C(COCCOCCCCCCNC[C@H](O)C2=CC=C(O)C(CO)=C2)C(Cl)=CC=C1
InChi Code
InChI=1S/C24H33Cl2NO5/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28/h5-9,14,24,27-30H,1-4,10-13,15-17H2/t24-/m0/s1
InChi Key
DAFYYTQWSAWIGS-DEOSSOPVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $41

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    1 mg

    $75

    Add

    5 mg

    $293

    Add
    Product Description

    Vilanterol is a long-acting agonist of the β2-adrenergic receptor (β2-AR).1 It selectively induces cAMP accumulation in CHO cells expressing the β2-AR over the β1- and β3-ARs (EC50s = 0.4, 398, and 794 nM for the human receptors, respectively). Vilanterol inhibits contractions induced by electrical stimulation in isolated superfused guinea pig trachea strips. It inhibits bronchospasms induced by histamine (Item No. 33828) in guinea pigs when administered via nebulization (EC50 = 30 µM). Formulations containing vilanterol, in combination with fluticasone, have been used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Procopiou, P.A., Barrett, V.J., Bevan, N.J., et al. Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: An antedrug approach. J. Med. Chem. 53(11), 4522-4530 (2010).