Pyrrolidinedithiocarbamic Acid (ammonium salt)

Pyrrolidinedithiocarbamic acid (PDTC) is a metal chelating compound that potently and reversibly inhibits NF-κB activation in vitro (100 µM).¹ At 300 µM, it prevents TNF-α gene expression and protein production in human monocytes after LPS application.² In vascular smooth muscle cells, PDTC (10 µM) arrests the cell cycle at the G₁ phase with upregulation of p21^Cip1 through the p38 MAPK pathway.³ PDTC (100 µM) also has antioxidant properties.⁴

WARNING This product is not for human or veterinary use.

1. Schreck, R., Meier, B., Männel, D.N., et al. Dithiocarbamates as potent inhibitors of nuclear factor κΒ activation in intact cells. J. Exp. Med. 175(5), 1181-1194 (1992).

2. Ziegler-Heitbrock, H.W.L., Sternsdorf, T., Liese, J., et al. Pyrrolidine dithiocarbamate inhibits NF-κΒ mobilization and TNF production in human monocytes. J. Immunol. 151(12), 6986-6993 (1993).

3. Moon, S.-K., Jung, S.-Y., Choi, Y.-H., et al. PDTC, metal chelating compound, induces G₁ phase cell cycle arrest in vascular smooth muscle cells through inducing p21Cip1 expression: Involvement of p38 mitogen activated protein kinase. J. Cell. Physiol. 198(2), 310-323 (2004).

4. Xu, S., Liu, Z., Huang, Y., et al. Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation. Transl. Res. 160(2), 114-124 (2012).