A nootropic phospholipid
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Labeled Version(s)
26099sn-glycero-3-Phosphocholine-d9
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sn-glycero-3-Phosphocholine

Item No. 20736

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[[(2R)-2,3-dihydroxypropoxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-ethanaminium, inner salt
CAS Number
28319-77-9
Synonyms
  • Glycerophosphocholine
  • L-α-GPC
  • L-α-Glycerylphosphorylcholine
  • sn-glycero-3-PC
Molecular Formula
C8H20NO6P
Formula Weight
257.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: 1 mg/mLPBS (pH 7.2): 3 mg/mL
SMILES
OC[C@@H](O)COP(OCC[N+](C)(C)C)([O-])=O
InChi Code
InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/t8-/m1/s1
InChi Key
SUHOQUVVVLNYQR-MRVPVSSYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 g

    $49

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    5 g

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    10 g

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    25 g

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    Product Description

    sn-glycero-3-Phosphocholine (sn-glycero-3-PC) is a nootropic phospholipid, a precursor to choline biosynthesis, and an intermediate in the metabolism of phosphatidylcholine.1 In vivo, sn-glycero-3-PC is converted to phosphorylcholine, a metabolically active form of choline that increases acetylcholine synthesis and release in rat hippocampus. It prevents scopolamine-induced amnesia in a passive avoidance test in rats and exerts neuroprotective effects in models of altered cholinergic neurotransmission and models of brain vascular injury.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Traini, E., Bramanti, V., and Amenta, F. Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipid with a still interesting profile as cognition enhancing agent. Curr. Alzheimer Res. 10(10), 1070-1079 (2013).

    2. Sigala, S., Imperato, A., Rizzonelli, P., et al. L-α-glycerylphosphorylcholine antagonizes scopolamine-induced amnesia and enhances hippocampal cholinergic transmission in the rat. Eur. J. Pharmacol. 211(3), 351-358 (1992).