An active metabolite of L-DOPA
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Parent Compound(s)
13248L-DOPA
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3-O-methyl-L-DOPA (hydrate)

Item No. 20737

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methoxy-L-tyrosine, monohydrate
CAS Number
200630-46-2
Synonyms
  • 3-O-methyl-3,4-Dihydroxyphenylalanine
  • 3-methoxy DOPA
  • 3-OMD
Molecular Formula
C10H13NO4 • H2O
Formula Weight
229.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
λmax
278 nm
SMILES
OC1=C(OC)C=C(C[C@H](N)C(O)=O)C=C1.O
InChi Code
InChI=1S/C10H13NO4.H2O/c1-15-9-5-6(2-3-8(9)12)4-7(11)10(13)14;/h2-3,5,7,12H,4,11H2,1H3,(H,13,14);1H2/t7-;/m0./s1
InChi Key
IDRRCKUGGXLORG-FJXQXJEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $28

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    5 mg

    $72

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    10 mg

    $102

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    25 mg

    $223

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    Product Description

    3-O-methyl-L-DOPA is an active metabolite of L-DOPA (Item No. 13248).1 It is formed from L-DOPA via O-methylation by catechol-O-methyltransferase (COMT). 3-O-methyl-L-DOPA (10 and 100 µM) inhibits L-DOPA-induced neuroprotection in primary rat mesencephalic dopaminergic neurons.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miller, J.W., Shukitt-Hale, B., Villalobos-Molina, R., et al. Effect of ʟ-Dopa and the catechol-O-methyltransferase inhibitor Ro 41-0960 on sulfur amino acid metabolites in rats. Clin. Neuropharmacol. 20(1), 55-66 (1997).

    2. Asanuma, M., and Miyazaki, I. 3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of ʟ-DOPA. BMC Neurosci. 17(1), 52 (2016).