An aminobisphosphonate and antimalarial agent
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Risedronate (sodium salt)

Item No. 20740

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P,P'-[1-hydroxy-2-(3-pyridinyl)ethylidene]bis-phosphonic acid, monosodium salt
CAS Number
115436-72-1
Molecular Formula
C7H10NO7P2 • Na
Formula Weight
305.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
262 nm
SMILES
OC(P(O)(O)=O)(P(O)([O-])=O)CC1=CC=CN=C1.[Na+]
InChi Code
InChI=1S/C7H11NO7P2.Na/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6;/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15);/q;+1/p-1
InChi Key
DRFDPXKCEWYIAW-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    250 mg

    $36

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    500 mg

    $68

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    1 g

    $123

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    5 g

    $502

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    Product Description

    Risedronate is a heterocyclic orally active aminobisphosphonate.1 Like other bisphosphonates, it inhibits bone resorption.2,1 In addition, it has antimalarial activity and inhibits growth of P. falciparum in vitro (IC50 = 20.3 µM) and P. berghei in vivo (25 mg/kg for one week).3 It also inhibits protein prenylation by preventing the transfer of a farnesyl pyrophosphate group to parasite proteins. Formulations containing risedronate have been used to reduce fracture risk in both age- and steroid-related osteoporosis.4,2,1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nuti, R. Updates on mechanism of action and clinical efficacy of risedronate in osteoporosis. Clin. Cases Miner. Bone Metab. 11(3), 208-214 (2014).

    2. Lems, W.F., and den Heijer, M. Established and forthcoming drugs for the treatment of osteoporosis. Neth. J. Med. 71(4), 188-193 (2013).

    3. Jordao, F.M., Saito, A.Y., Miguel, D.C., et al. In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum. Antimicrob. Agents Chemother. 55(5), 2026-2031 (2011).

    4. Pereira, R.M.R., de Carvalho, J.F., Paula, A.P., et al. Guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis. Rev. Bras. Reumatol. 52(4), 580-593 (2012).