An inhibitor of midasin
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Rbin-1

Item No. 20745

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(2-methyl-2-propen-1-yl)thio]-5H-1,2,4-triazino[5,6-b]indole
CAS Number
328023-11-6
Synonyms
  • Ribozinoindole-1
Molecular Formula
C13H12N4S
Formula Weight
256.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 25 mg/ml
λmax
224, 266, 346 nm
SMILES
C=C(C)CSC(N=N1)=NC2=C1C3=CC=CC=C3N2
InChi Code
InChI=1S/C13H12N4S/c1-8(2)7-18-13-15-12-11(16-17-13)9-5-3-4-6-10(9)14-12/h3-6H,1,7H2,2H3,(H,14,15,17)
InChi Key
LPCWHNSRTRBKBO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $103

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    5 mg

    $427

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    Product Description

    Rbin-1 is a triazinoindole inhibitor of midasin (mdn1), an essential protein for eukaryotic ribosome biogenesis.1 It inhibits the growth of fission yeast strains in vitro (GI50 = 136 nM) and inhibits mdn1 ATPase activity by approximately 40% when used at a concentration of 1 µM. Rbin-1 inhibits pre-rRNA processing and nuclear export of the pre-60S ribosome subunit in mdn1-ts, but not mdn1-F1093L mutant, S. pombe cells. It also decreases ribosome assembly protein 4 (Rsa4) levels in Rix1 particles, a ribosome assembly intermediate, Rix1-bound Ytm1 levels, and Rix7 and Ppp1 levels in the nucleolar pre-60S particle Nsa1 in mdn1-ts fission yeast cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kawashima, S.A., Chen, Z., Aoi, Y., et al. Potent, reversible, and specific chemical inhibitors of eukaryotic ribosome biogenesis. Cell 167(2), 512-524 (2016).