A more lipid soluble form of 11(Z),14(Z)-eicosadienoic acid
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11(Z),14(Z)-Eicosadienoic Acid methyl ester

Item No. 20750

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11Z,14Z-eicosadienoic acid, methyl ester
CAS Number
61012-46-2
Synonyms
  • SFE 21:2
Molecular Formula
C21H38O2
Formula Weight
322.5
Purity
≥98%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 0.5 mg/ml
λmax
267, 280, 362 nm
SMILES
CCCCC/C=C\C/C=C\CCCCCCCCCC(OC)=O
InChi Code
InChI=1S/C21H38O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21(22)23-2/h7-8,10-11H,3-6,9,12-20H2,1-2H3/b8-7-,11-10-
InChi Key
GWJCFAOQCNNFAM-NQLNTKRDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $28

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    10 mg

    $50

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    50 mg

    $104

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    100 mg

    $124

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    Product Description

    11(Z),14(Z)-Eicosadienoic acid methyl ester is a more lipid soluble form of the ω-6 C20-2 fatty acid 11(Z),14(Z)-eicosadienoic acid (Item No. 90330), a naturally occurring PUFA. 11(Z),14(Z)-Eicosadienoic acid competitively inhibits inosine 5’-monophosphate dehydrogenase (Ki = 3.1 µM) and inhibits the binding of LTB4 to its receptor on neutrophils (Ki = 3.0 µM).1,2 Also, serum levels of eicosadienoic acids negatively correlate with degree of sleep disturbance.3 Eicosadienoic acids are converted by desaturases, in vivo, to eicosatrienoic acids, which are potent vasodilators.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mizushina, Y., Dairaku, I., Yanaka, N., et al. Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase. Biochimie 89(5), 581-590 (2007).

    2. Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins, Leukot. Essent. Fatty Acids 52(5), 293-297 (1995).

    3. Irmisch, G., Schläfke, D., Gierow, W., et al. Fatty acids and sleep in depressed inpatients. Prostaglandins, Leukot. Essent. Fatty Acids 76(1), 1-7 (2007).