A semisynthetic echinocandin antifungal
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Anidulafungin

Item No. 20753

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(4R,5R)-4,5-dihydroxy-N2-[[4''-(pentyloxy)[1,1':4',1''-terphenyl]-4-yl]carbonyl]-L-ornithine]-echinocandin B
CAS Number
166663-25-8
Synonyms
  • LY303366
  • VER-002
Molecular Formula
C58H73N7O17
Formula Weight
1140.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
303 nm
SMILES
O=C1[C@@]([C@@H](O)[C@@H](C)C2)([H])N2C([C@@]([C@H](O)C)([H])NC([C@H]([C@H](O)[C@@H](O)C3=CC=C(O)C=C3)NC([C@@]4([H])N(C([C@H]([C@H](O)C)NC([C@@H](NC(C5=CC=C(C6=CC=C(C7=CC=C(OCCCCC)C=C7)C=C6)C=C5)=O)C[C@@H](O)[C@@H](O)N1)=O)=O)C[C@H](O)C4)=O)=O)=O
InChi Code
InChI=1S/C58H73N7O17/c1-5-6-7-24-82-40-22-18-35(19-23-40)33-10-8-32(9-11-33)34-12-14-37(15-13-34)51(74)59-41-26-43(70)54(77)63-56(79)47-48(71)29(2)27-65(47)58(81)45(31(4)67)61-55(78)46(50(73)49(72)36-16-20-38(68)21-17-36)62-53(76)42-25-39(69)28-64(42
InChi Key
JHVAMHSQVVQIOT-MFAJLEFUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Anidulafungin is a semisynthetic echinocandin antifungal.1 It inhibits 1,3-β-D glucan synthase from several C. albicans clinical isolates (IC50s = 0.89-7.96 ng/ml for the wild-type enzyme).2 Anidulafungin is active against various Candida species, including C. albicans, C. parapsilosis, C. tropicalis, and C. guiillermondi (MICs = ≤0.03-4 µg/ml), as well as A. fumigatus (MIC90 = ≤0.03 µg/ml).1 It increases survival and decreases the severity of pulmonary lesions in A. fumigatus-infected neutropenic rabbits when administered at a dose of 10 mg/kg.3 Formulations containing anidulafungin have been used in the treatment of candidemia and candidiasis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vazquez, J.A., and Sobel, J.D. Anidulafungin: A novel echinocandin. Clin. Infect. Dis. 43(2), 215-222 (2006).

    2. Garcia-Effron, G., Park, S., and Perlin, D.S. Correlating echinocandin MIC and kinetic inhibition of fks1 mutant glucan synthases for Candida albicans: Implications for interpretive breakpoints. Antimicrob Agents Chemother. 53(1), 112-122 (2009).

    3. Petraitis, V., Petraitiene, R., Groll, A.H., et al. Antifungal efficacy, safety, and single-dose pharmacokinetics of LY303366, a novel echinocandin B, in experimental pulmonary aspergillosis in persistently neutropenic rabbits. Antimicrob Agents Chemother. 42(11), 2898-2905 (1998).