An internal standard for the quantification of maresin 2
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Maresin 2-d5

Item No. 20757

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
13R,14S-dihydroxy-4Z,7Z,9E,11E,16Z,19Z-docosahexaenoic-21,21,22,22,22-d5 acid
Synonyms
  • 13R,14S-diHDHA-d5
  • 13R,14S-dihydroxy Docosahexaenoic Acid-d5
  • MaR2-d5
Molecular Formula
C22H27D5O4
Formula Weight
365.5
Purity
≥99% deuterated forms (d1-d5)
Formulation
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 0.05 mg/ml
λmax
274, 285 nm
SMILES
O[C@@H](C/C=C\C/C=C\C([2H])([2H])C([2H])([2H])[2H])[C@H](O)/C=C/C=C/C=C\C/C=C\CCC(O)=O
InChi Code
InChI=1S/C22H32O4/c1-2-3-4-5-11-14-17-20(23)21(24)18-15-12-9-7-6-8-10-13-16-19-22(25)26/h3-4,6-7,9-15,18,20-21,23-24H,2,5,8,16-17,19H2,1H3,(H,25,26)/b4-3-,7-6-,12-9+,13-10-,14-11-,18-15+/t20-,21+/m0/s1/i1D3,2D2
InChi Key
ALWYOLKNLLFCAY-VLKIHEMDSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 µg

    $208

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    25 µg

    $416

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    50 µg

    $729

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    100 µg

    $1,248

    Add
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    Product Description

    Maresin 2-d5 (MaR2-d5) contains 5 deuterium atoms at the 21, 21, 22, 22, and 22 positions. It is intended for use as an internal standard for the quantification of MaR2 (Item No. 16369) by GC- or LC-MS. MaR2 is a 13R,14S-dihydroxy DHA formed by recombinant human macrophage 12-lipoxygenase and soluble epoxide hydrolase co-incubated with DHA.1 At 1 ng/mouse, MaR2 was shown to reduce neutrophil infiltration by 40% in a mouse model of peritonitis, and at 10 pM, MaR2 can enhance human macrophage phagocytosis of zymosan A by 90%.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Deng, B., Wang, C.W., Arnardottir, H.H., et al. Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages. PLoS One 9(7), (2014).

    Product Citations

    Sugimoto, S., Mena, H.A., Sansbury, B.E., et al. Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation. Nat. Metab. 4(6), 775-790 (2022).