A triptan
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Pizotifen (malate)

Item No. 20765

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine, 2-hydroxy-butanedioic acid
CAS Number
5189-11-7
Molecular Formula
C19H21NS • C4H6O5
Formula Weight
429.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:8): 0.11 mg/mlDMSO: 15 mg/mlEthanol: 0.5 mg/ml
SMILES
CN(CC/1)CCC1=C2C3=C(C=CC=C3)CCC4=C/2C=CS4.OC(C(O)=O)CC(O)=O
InChi Code
InChI=1S/C19H21NS.C4H6O5/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18;5-2(4(8)9)1-3(6)7/h2-5,10,13H,6-9,11-12H2,1H3;2,5H,1H2,(H,6,7)(H,8,9)
InChi Key
IWAWCPZVTXCFKD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $31

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    250 mg

    $66

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    500 mg

    $86

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    1 g

    $129

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    Product Description

    Pizotifen is a triptan with high affinity for serotonin (5-HT) and dopamine receptors (Kis = 7.94 and 2.4 nM for 5-HT2C and D2, respectively).1,2 It is used for the prophylaxis of migraine headaches.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Glusa, E., and Pertz, H.H. Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT2B receptors. Br. J. Pharmacol. 130(3), 692-698 (2000).

    2. Morimoto, A., Yamada, H., Watanabe, T., et al. Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists. Bioorg. Med. Chem. 21(24), 7841-7852 (2013).

    3. Pringsheim, T., Davenport, W.J., and Becker, W.J. Prophylaxis of migraine headache. CMAJ 182(7), (2010).