An orally active ACE inhibitor
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Active Metabolite(s)
17574Perindoprilat
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Perindopril

Item No. 20796

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid
CAS Number
82834-16-0
Molecular Formula
C19H32N2O5
Formula Weight
368.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: 25 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
[H][C@]12[C@](N(C([C@H](C)N[C@@H](CCC)C(OCC)=O)=O)[C@H](C(O)=O)C2)([H])CCCC1
InChi Code
InChI=1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,15-,16-/m0/s1
InChi Key
IPVQLZZIHOAWMC-QXKUPLGCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 mg

    $75

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    250 mg

    $168

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    500 mg

    $295

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    1 g

    $442

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    Product Description

    Perindopril is an orally active angiotensin converting enzyme (ACE) inhibitor that effectively lowers blood pressure.1,2 It is a prodrug that is metabolized to perindoprilat (Item No. 17574), a specific, competitive inhibitor of ACE (IC50 = 1.5-3.2 nM in vitro).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sennesael, J., Ali, A., Sweny, P., et al. The pharmacokinetics of perindopril and its effects of serum angiotensin converting enzyme activity in hypertensive patients with chronic renal failure. Br. J. Clin. Pharmac. 33, 93-99 (1992).

    2. Wang, J.g., Pimenta, E., and Chwallek, F. Comparative review of the blood pressure-lowering and cardiovascular benefits of telmisartan and perindopril. Vasc. Health Risk Manag. 10, 189-200 (2014).

    3. Vago, T., Bevilacqua, M., Conci, F., et al. Angiotensin converting enzyme binding sites in human heart and lung: Comparison with rat tissues. Br. J. Pharmacol. 107(3), 821-825 (1992).