An α1 Na+/K+ ATPase sodium pump inhibitor
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Isomer(s)
39822Desacetylcinobufagin
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Marinobufagenin

Item No. 20798

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,5β,15β)-14,15-epoxy-3,5-dihydroxy-bufa-20,22-dienolide
CAS Number
470-42-8
Synonyms
  • Marinobufagin
  • MBG
  • NSC 234205
Molecular Formula
C24H32O5
Formula Weight
400.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMF:PBS (pH 7.2) (1:8): 0.1 mg/mlEthanol: 1 mg/ml
λmax
297 nm
SMILES
O[C@H]1CC[C@@]2(C)[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@]3(O5)[C@H]5C[C@@H]4C6=COC(C=C6)=O)(O)C1
InChi Code
InChI=1S/C24H32O5/c1-21-8-5-15(25)12-23(21,27)10-7-17-16(21)6-9-22(2)18(11-19-24(17,22)29-19)14-3-4-20(26)28-13-14/h3-4,13,15-19,25,27H,5-12H2,1-2H3/t15-,16-,17+,18+,19+,21+,22+,23-,24+/m0/s1
InChi Key
JMNQTHQLNRILMH-OBBGIPBRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Marinobufagenin (MBG) is a bufadienolide steroid first isolated from toads of genus Bufo. It can also be excreted by mammalian cells, particularly kidney cells from hypertensive animals.1 MBG inhibits the ouabain-resistant α1 Na+/K+ ATPase subunit (IC50 = 78 nM), impairing a major sodium pump of the kidneys, resulting in natriuresis and arterial hypertension.1,2 Serum and urine levels of MBG are also elevated after cardiac infarction, and a reduced form of MBG, marinobufotoxin, occurs in the plasma of patients with terminal renal failure.3,2 Through its effects on the α1 Na+/K+ ATPase subunit, MBG has profound immediate and prolonged effects on kidney, heart, and vascular functions.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fedorova, O.V., Kolodkin, N.I., Agalakova, N.I., et al. Marinobufagenin, an endogenous alpha-1 sodium pump ligand, in hypertensive Dahl salt-sensitive rats. Hypertension 37(2 Pt 2), 462-466 (2001).

    2. Schoner, W., and Scheiner-Bobis, G. Role of endogenous cardiotonic steroids in sodium homeostasis. Nephrol. Dial. Transplant. 23(9), 2723-2729 (2008).

    3. Schoner, W. Endogenous cardiac glycosides, a new class of steroid hormones. Eur. J. Biochem. 269(10), 2440-2448 (2002).