A cell-permeable inhibitor of caspase-3 activation
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M50054

Item No. 20810

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2'-methylenebis-1,3-cyclohexanedione
CAS Number
54135-60-3
Molecular Formula
C13H16O4
Formula Weight
236.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
λmax
254 nm
SMILES
O=C(CCC1)C(CC2C(CCCC2=O)=O)C1=O
InChi Code
InChI=1S/C13H16O4/c14-10-3-1-4-11(15)8(10)7-9-12(16)5-2-6-13(9)17/h8-9H,1-7H2
InChi Key
ILUMEPMGPCKGHH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $86

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    10 mg

    $135

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    25 mg

    $294

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    Product Description

    M50054 is a cell-permeable inhibitor of the activation of caspase-3, blocking characteristic features of apoptosis, including DNA fragmentation and externalization of phosphatidylserine.1 It blocks apoptosis in a variety of cell lines induced by different stimuli, including Fas ligand and etoposide (Item No. 12092).1 M50054 has been used to inhibit apoptosis in skin, Xenopus larvae, teleost fish, and planaria, particularly in the context of tissue regeneration.2,3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tsuda, T., Ohmori, Y., Muramatsu, H., et al. Inhibitory effect of M50054, a novel inhibitor of apoptosis, on anti-FAS-antibody-induced hepatitis and chemotherapy-induced alopecia. Eur. J. Pharmacol. 433(1), 37-45 (2001).

    2. Beane, W.S., Morokuma, J., Lemire, J.M., et al. Bioelectric signaling regulates head and organ size during planarian regeneration. Develop. 140, 313-322 (2013).

    3. Durant, F., Lobo, D., Hammelman, J., et al. Physiological controls of large-scale patterning in planarian regeneration: A molecular and computational perspective on growth and form. Regeneration 3(2), 78-102 (2016).

    4. Tseng, A.-S., Adams, D.S., Qiu, D., et al. Apoptosis is required during early stages of tail regeneration in Xenopus laevis. Dev. Biol. 301(1), 62-69 (2007).

    5. Sirbulescu, R.F., and Zupanc, G.K. Inhibition of caspase-3-mediated apoptosis improves spinal cord repair in a regeneration-competent vertebrate system. Neuroscience 171(2), 599-612 (2010).