A non-selective myosin ATPase inhibitor
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2,3-Butanedione-2-monoxime

Item No. 20828

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3-butanedione, 2-oxime
CAS Number
57-71-6
Synonyms
  • BDM
  • Diacetyl Monoxime
  • NSC 660
  • NSC 116103
Molecular Formula
C4H7NO2
Formula Weight
101.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
229 nm
SMILES
CC(/C(C)=N/O)=O
InChi Code
InChI=1S/C4H7NO2/c1-3(5-7)4(2)6/h7H,1-2H3/b5-3+
InChi Key
FSEUPUDHEBLWJY-HWKANZROSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $22

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    25 g

    $40

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    50 g

    $53

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    100 g

    $70

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    Product Description

    2,3-Butanedione-2-monoxime (BDM) is a non-selective, reversible myosin ATPase inhibitor with phosphatase-like properties.1,2 It demonstrates direct and indirect actions on cardiac and vascular smooth muscle, inhibiting L-type Ca2+ channels.3,4 BDM has been shown to be involved in a number of biological activities, including muscle contraction and synaptic transmission.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sellin, L.C., and McArdle, J.J. Multiple effects of 2,3-butanedione monoxime. Pharmacol. Toxicol. 74(6), 305-313 (1994).

    2. Ostap, E.M. 2,3-Butanedione monoxime (BDM) as a myosin inhibitor. J. Muscle Res. Cell Motil. 23(4), 305-308 (2002).

    3. Eisfeld, J., Mikala, G., Varadi, G., et al. Inhibition of cloned human L-type cardiac calcium channels by 2,3-butanedione monoxime does not require PKA-dependent phosphorylation sites. Biochem. Biophys. Res. Commun. 230(3), 489-492 (1997).

    4. Adhikari, B.B., and Wang, K. Interplay of troponin- and myosin-based pathways of calcium activation in skeletal and cardiac muscle: The use of W7 as an inhibitor of thin filament activation. Biophys. J. 86(1), 359-370 (2004).