An NSAID
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Etodolac

Item No. 20833

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,8-diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indole-1-acetic acid
CAS Number
41340-25-4
Synonyms
  • AY 24236
  • (±)-Etodolac
  • NIH 9918
  • NSC 282126
Molecular Formula
C17H21NO3
Formula Weight
287.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 0.25 mg/ml
λmax
224, 273 nm
SMILES
CCC1(CC(O)=O)OCCC2=C1NC3=C2C=CC=C3CC
InChi Code
InChI=1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20)
InChi Key
NNYBQONXHNTVIJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    25 g

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    Product Description

    Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits both COX isoforms in vitro, with modest selectivity for COX-2 (IC50s = 12 µM for COX-1 and 2.2 µM for COX-2 in a human whole blood assay).1 Experimental evidence suggests that etodolac may have favorable tissue pharmacokinetics resulting in further COX-2 selectivity, indicated by favorable reduction in anti-inflammatory action with diminished gastric side effects.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Warner, T.D., Giuliano, F., Vojnovic, I., et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proc. Natl. Acad. Sci. USA 96(13), 7563-7568 (1999).

    2. Dvornik, D.M. Tissue selective inhibition of prostaglandin biosynthesis by etodolac. J. Rheumatol. 24, 40-50 (1997).

    3. Riendeau, D., Percival, M.D., Brideau, C., et al. Etoricoxib (MK-0663): Preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. J. Pharmacol. Exp. Ther. 296, 558-566 (2001).