An anthelmintic agent
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Cambendazol

Item No. 20841

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(4-thiazolyl)-1H-benzimidazol-6-yl]-carbamic acid, 1-methylethyl ester
CAS Number
26097-80-3
Synonyms
  • Isopropyl 2-(4-thiazolyl)-5-benzimidazolecarbamate
  • MK-905
  • NSC 377071
Molecular Formula
C14H14N4O2S
Formula Weight
302.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/ml
λmax
235, 324 nm
SMILES
CC(C)OC(NC1=CC=C(N=C(C2=CSC=N2)N3)C3=C1)=O
InChi Code
InChI=1S/C14H14N4O2S/c1-8(2)20-14(19)16-9-3-4-10-11(5-9)18-13(17-10)12-6-21-7-15-12/h3-8H,1-2H3,(H,16,19)(H,17,18)
InChi Key
QZWHWHNCPFEXLL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $29

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    10 mg

    $48

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    50 mg

    $96

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    100 mg

    $125

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    Cayman Chemical
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    Product Description

    Cambendazol is an antihelmintic that, at a dose of 50 mg/kg/day in mice, eradicates S. ratti adult worms from intestine and S. stercoralis larva from muscle.1 It inhibits polymerization of microtubules isolated from bovine brain with an IC50 value of 64.2 µM.2 Formulations containing cambendazol have been used to treat strongyloidiasis in humans and have been studied as potential chemotherapeutics.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Grove, D.I. Strongyloides ratti and S. stercoralis: The effects of thiabendazole, mebendazole, and cambendazole in infected mice. Am. J. Trop. Med. Hyg. 31(3 Pt 1), 469-476 (1982).

    2. Friedman, P.A., and Platzer, E.G. Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin. Biochim. Biophys. Acta 544(3), 605-614 (1978).

    3. Bichalho, S.A., Leão, O.J., and Pena, Q.J. Cambendazole in the treatment of human strongyloidiasis. Am. J. Trop. Med. Hyg. 32(5), 1181-1183 (1983).

    4. Dunn, W.A.J., Akin, D.E., Progulske-Fox, A., et al. Methods and compositions for the treatment of cancers and pathogenic infections. Patent Application Publication 1-7 (2010).