An anti-inflammatory agent
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Actarit

Item No. 20852

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(acetylamino)-benzeneacetic acid
CAS Number
18699-02-0
Synonyms
  • 4-Acetylaminophenylacetic Acid
  • MS-932
  • NSC 170317
Molecular Formula
C10H11NO3
Formula Weight
193.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2)(1:9): 0.1 mg/mlEthanol: 3 mg/ml
λmax
246 nm
SMILES
CC(NC1=CC=C(CC(O)=O)C=C1)=O
InChi Code
InChI=1S/C10H11NO3/c1-7(12)11-9-4-2-8(3-5-9)6-10(13)14/h2-5H,6H2,1H3,(H,11,12)(H,13,14)
InChi Key
MROJXXOCABQVEF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $75

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    10 g

    $120

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    25 g

    $204

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    50 g

    $333

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    Product Description

    Actarit is an anti-inflammatory agent.1,2 It inhibits carbonic anhydrase II (CAII; IC50 = 422 nM).3 Actarit decreases disease severity in a mouse model of arthritis induced by type II collagen, as well as in a rat model of experimental autoimmune encephalomyelitis (EAE).1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fujisawa, H., Nishimura, T., Motonaga, A., et al. Effect of actarit on type II collagen-induced arthritis in mice. Arznei.-Forschung 44(1), 64-68 (1994).

    2. Kawai, K., Kobayashi, Y., Hirayama, M., et al. Suppressive effects of 4-acetylaminophenylacetic acid (actarit) on experimental autoimmune encephalomyelitis in rats. Immunopharmacol. 39(2), 127-138 (1998).

    3. Ghislat, G., Rahman, T., and Ballester, P.J. Identification and validation of carbonic anhydrase II as the first target of the anti-inflammatory drug actarit. Biomolecules 10(11), 1570 (2020).