A PDE5 inhibitor
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MY-5445

Item No. 20872

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-chlorophenyl)-4-phenyl-1-phthalazinamine
CAS Number
78351-75-4
Molecular Formula
C20H14ClN3
Formula Weight
331.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
λmax
215, 336 nm
SMILES
ClC1=CC=CC(NC(C2=C3C=CC=C2)=NN=C3C4=CC=CC=C4)=C1
InChi Code
InChI=1S/C20H14ClN3/c21-15-9-6-10-16(13-15)22-20-18-12-5-4-11-17(18)19(23-24-20)14-7-2-1-3-8-14/h1-13H,(H,22,24)
InChi Key
CEHQLKSLMFIHBF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $169

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    25 mg

    $378

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    Product Description

    MY-5445 is a selective inhibitor of the cyclic GMP (cGMP) phosphodiesterase, PDE5, with a Ki value of 1.3 µM.1,2 It inhibits calcium- and cAMP-selective PDEs with Ki values of >1,000 and 915 µM, respectively.1 MY-5445 has been shown to relax intact strips of rat aorta with an EC50 value of 4 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Souness, J.E., Brazdil, R., Diocee, B.K., et al. Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine. Br. J. Pharmacol. 98(3), 725-734 (1989).

    2. Yamamoto, T., Yamamaoto, S., Osborne, J.C., Jr., et al. Complex effects of inhibitors on cyclic GMP-stimulated cyclic nucleotide phosphodiesterase. The Journal of Biological Chemisty 258(23), 14173-14177 (1983).