MHC Class I Monoclonal Antibody (Clone W6/32)

Major histocompatibility complex (MHC) molecules, also designated human leukocyte antigen (HLA) molecules, are cell-surface receptors that bind foreign peptides and present them to T lymphocytes.¹ MHC class I molecules consist of two polypeptide chains, an α or heavy chain, and β2-microglobulin, a non-covalently associated protein.² Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules.³ Antigens that bind to MHC class I molecules are typically 8-10 residues in length and are stabilized in a peptide binding groove.⁴ HLA-class I MHC antigens are intrinsic membrane glycoproteins expressed on nucleated cells and non-covalently associated with an invariant β2-microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells and are thus important for antiviral and antitumor defense. ³ Human HLA-class I antigens are represented by HLA-A, HLA-B, and HLA-C molecules

WARNING This product is not for human or veterinary use.

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