An ENPP2 inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

CRT0273750

Item No. 20904

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S)-1-(4-chlorophenyl)ethyl]-3-[[4-(trifluoromethoxy)phenyl]methyl]-3H-imidazo[4,5-b]pyridine-2-propanamide
CAS Number
1979939-16-6
Molecular Formula
C25H22ClF3N4O2
Formula Weight
502.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mLDMSO: 16 mg/mLEthanol: 5 mg/mL
SMILES
O=C(N[C@@H](C)C1=CC=C(Cl)C=C1)CCC2=NC3=CC=CN=C3N2CC4=CC=C(OC(F)(F)F)C=C4
InChi Code
InChI=1S/C25H22ClF3N4O2/c1-16(18-6-8-19(26)9-7-18)31-23(34)13-12-22-32-21-3-2-14-30-24(21)33(22)15-17-4-10-20(11-5-17)35-25(27,28)29/h2-11,14,16H,12-13,15H2,1H3,(H,31,34)/t16-/m0/s1
InChi Key
HXYXHSDYBDFOFO-INIZCTEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $158

    Add

    10 mg

    $279

    Add

    25 mg

    $610

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    CRT0273750 is an ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2) inhibitor (IC50 = 1 nM).1 It prevents lysophosphatidylcholine hydrolysis in a plasma choline release assay (IC50 = 13 nM). CRT0273750 inhibits the migration of 4T1 cells in a migration assay (IC50 = 24 nM). It decreases plasma levels of the ENPP2 hydrolysis product lysophosphatidic acid in an MDA-MB-231 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shah, P., A., C., Foxton, C., et al. Discovery of potent inhibitors of the lysophospholipase autotaxin. Bioorg. Med. Chem. Lett. 26(22), 5403-5410 (2016).