A potent agonist of GPR54
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Metastin (45-54)

Item No. 20905

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tyrosyl-L-asparaginyl-L-tryptophyl-L-asparaginyl-L-seryl-L-phenylalanylglycyl-L-leucyl-L-arginyl-L-phenylalaninamide
CAS Number
374675-21-5
Synonyms
  • Kisspeptin-10 (human)
  • Kp-10 (human)
Molecular Formula
C63H83N17O14
Formula Weight
1302.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 15 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml
λmax
278 nm
SMILES
O=C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CC1=CC=CC=C1)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)[C@@H](NC([C@H](CC(N)=O)NC([C@@H](N)CC3=CC=C(O)C=C3)=O)=O)CC4=CNC5=CC=CC=C45
InChi Code
InChI=1S/C63H83N17O14/c1-34(2)24-45(58(90)74-43(18-11-23-70-63(68)69)57(89)75-44(54(67)86)26-35-12-5-3-6-13-35)73-53(85)32-72-56(88)46(27-36-14-7-4-8-15-36)77-62(94)50(33-81)80-61(93)49(30-52(66)84)79-59(91)47(28-38-31-71-42-17-10-9-16-40(38)42)78-60
InChi Key
RITKWYDZSSQNJI-INXYWQKQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Metastin (45-54) is a 10 amino acid peptide that corresponds to the bioactive C-terminal 45-54 amino acids of metastin, a metastasis suppressor gene product.1 It acts as a potent agonist of GPR54 (OT7T175, AXOR12), with approximately 8-fold higher binding affinity than metastin (Ki values of 0.042 and 0.34 nM, respectively, for displacement of metastin (40-54)).1 Metastin (45-54) induces calcium mobilization in GPR54-transfected cells (EC50 = 0.18-1.1 nM).2 It inhibits the migration of GPR54-transfected CHO cells at concentrations of 10-100 nM, equaling the potency of full length metastin.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ohtaki, T., Shintani, Y., Honda, S., et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 411(6837), 613-617 (2001).

    2. Tomita, K., Niida, A., Osishi, S., et al. Structure-activity relationship study on small peptidic GPR54 agonists. Bioor. Med. Chem. Lett. 14(22), 7595-7603 (2006).

    3. Hori, A., Honda, S., Asada, M., et al. Metastin suppresses the motility and growth of CHO cells transfected with its receptor. Biochem. Biophys. Res. Commun. 286(5), 958-963 (2001).