A selective inhibitor of nNOS
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nNOS Inhibitor I

Item No. 20906

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N'-nitro-guanidine, tris(2,2,2-trifluoroacetate)
CAS Number
357965-99-2
Synonyms
  • Neuronal Nitric Oxide Synthase
  • NOS I
  • ncNOS
Molecular Formula
C8H21N7O2 • 3CF3COOH
Formula Weight
589.4
Purity
≥95%
Formulation
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Water: 50 mg/ml
λmax
269 nm
SMILES
N=C(NCCC[C@H](N)CNCCN)N[N+]([O-])=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C8H21N7O2.3C2HF3O2/c9-3-5-12-6-7(10)2-1-4-13-8(11)14-15(16)17;3*3-2(4,5)1(6)7/h7,12H,1-6,9-10H2,(H3,11,13,14);3*(H,6,7)/t7-;;;/m0.../s1
InChi Key
NYWNMNBIORWOSQ-QTPLPEIMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $75

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    1 mg

    $134

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    Product Description

    nNOS inhibitor I is a cell-permeable, selective inhibitor of nNOS (Ki = 120 nM).1 It displays >2,500-fold and 320-fold selectivity over eNOS and iNOS, respectively.1 It has been used in a rabbit model for cerebral palsy to prevent hypoxia-ischemia-induced death and to reduce the number of newborn kits exhibiting signs of cerebral palsy.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hah, J.-M., Roman, L.J., Martásek, P., et al. Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. J. Med. Chem. 44(16), 2667-2670 (2001).

    2. Ji, H., Tan, S., Igarashi, J., et al. Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy. Ann. Neurol. 65(2), 209-217 (2009).