A 3,6-dideoxyhexose terminal sugar and the immunodominant component of T. spiralis antigens
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Tyvelose

Item No. 20910

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,6-dideoxy-D-arabino-hexose
CAS Number
5658-12-8
Synonyms
  • D-Tyvelose
Molecular Formula
C6H12O4
Formula Weight
148.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C[C@H](C[C@@H]([C@@H](C)O)O)O
InChi Code
InChI=1S/C6H12O4/c1-4(8)6(10)2-5(9)3-7/h3-6,8-10H,2H2,1H3/t4-,5+,6+/m1/s1
InChi Key
GNTQICZXQYZQNE-SRQIZXRXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $90

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    Cayman Chemical
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    Product Description

    Tyvelose is an unusual 3,6-dideoxyhexose terminal sugar and the immunodominant component of glycoprotein antigens in the parasitic helminth T. spiralis, which is responsible for trichinosis in humans.1,2 It is produced in high amounts by the infective larva and is immunodominant during the muscle stage of infection. Mice immunized with tyvelose-BSA produce IgG1 antibodies to tyvelose but are not resistant to infection by T. spiralis.2 Tyvelose-specific antibodies (2.5 mg/20 g) administered to rat pups leads to expulsion of first stage larvae from the intestine within one hour.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wisnewski, N., McNeil, M., Grieve, R.B., et al. Characterization of novel fucosyl- and tyvelosyl-containing glycoconjugates from Trichinella spiralis muscle stage larvae. Mol. Biochem. Parasitol. 61(1), 25-35 (1993).

    2. Goyal, P.K., Wheatcroft, J., and Wakelin, D. Tyvelose and protective responses to the intestinal stages of Trichinella spiralis. Parasitol. Int. 51(1), 91-98 (2002).

    3. Blum, L.K., Mohanan, S., Fabre, M.V., et al. Intestinal infection with Trichinella spiralis induces distinct, regional immune responses. Vet. Parasitol. 194(2-4), 101-105 (2013).