A selective TRPV4 antagonist
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HC-067047

Item No. 20927

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
CAS Number
883031-03-6
Molecular Formula
C26H28F3N3O2
Formula Weight
471.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS(pH7.2) (1:2): 0.33 mg/mlDMSO: 15 mg/mlEthanol: 1 mg/ml
λmax
279 nm
SMILES
CC1=C(C(NC2=CC=CC(C(F)(F)F)=C2)=O)C=C(C3=CC=CC=C3)N1CCCN4CCOCC4
InChi Code
InChI=1S/C26H28F3N3O2/c1-19-23(25(33)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31/h2-5,7-10,17-18H,6,11-16H2,1H3,(H,30,33)
InChi Key
NCZYSQOTAYFTNM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $77

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    10 mg

    $135

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    25 mg

    $294

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    Product Description

    HC-067047 is a TRPV4 antagonist that reversibly inhibits currents through human, rat, and mouse TRPV4 orthologs (IC50s = 48, 133, and 17 nM, respectively).1 It is selective for TRPV4 over TRPV1, TRPV2, TRPV3, and TRPM8 channels.1 HC-067047 has been shown to increase functional bladder capacity and to reduce micturition frequency in wild-type mice and rats with cystitis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Everaerts, W., Zhen, X., Ghosh, D., et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc. Natl. Acad. Sci. USA 107(44), 19084-19089 (2010).