A glycogen phosphorylase inhibitor
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1,4-dideoxy-1,4-imino-D-Arabinitol (hydrochloride)

Item No. 20939

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2R-(hydroxymethyl)-3R,4R-pyrrolidinediol, monohydrochloride
CAS Number
100991-92-2
Synonyms
  • DAB
Molecular Formula
C5H11NO3 • HCl
Formula Weight
169.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
OC[C@H]1NC[C@@H](O)[C@@H]1O.Cl
InChi Code
InChI=1S/C5H11NO3.ClH/c7-2-3-5(9)4(8)1-6-3;/h3-9H,1-2H2;1H/t3-,4-,5-;/m1./s1
InChi Key
PZGVJCJRMKIVLJ-DEVUXVJFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

    $183

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    10 mg

    $322

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    25 mg

    $453

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    Product Description

    1,4-dideoxy-1,4-imino-D-Arabinitol (DAB) is an inhibitor of glycogen phosphorylase, a key enzyme in glycogenolysis. It inhibits glycogenolysis in isolated liver cells (IC50 = 1.0 µM) and in homogenates of cerebral cortex and cerebellum (IC50s = 463 and 383 nM, respectively).1,2,3 DAB is used to inhibit glycogenolysis, in liver and in brain, in various animal models.4,5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Andersen, B., and Westergaard, N. The effect of glucose on the potency of two distinct glycogen phosphorylase inhibitors. Biochem. J. 367(Pt. 2), 443-450 (2002).

    2. Andersen, B., Rassov, A., Westergaard, N., et al. Inhibition of glycogenolysis in primary rat hepatocytes by 1, 4-dideoxy-1,4-imino-D-arabinitol. Biochem. J. 342, 545-550 (1999).

    3. Walls, A.B., Sickmann, H.M., Brown, A., et al. Characterization of 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) as an inhibitor of brain glycogen shunt activity. J. Neurochem. 105(4), 1462-1470 (2008).

    4. Fosgerau, K., Westergaard, N., Quistorff, B., et al. Kinetic and functional characterization of 1,4-dideoxy-1, 4-imino-d-arabinitol: a potent inhibitor of glycogen phosphorylase with anti-hyperglyceamic effect in ob/ob mice. Arch. Biochem. Biophys. 380(2), 274-284 (2000).

    5. Gibbs, M.E. Role of Glycogenolysis in Memory and Learning: Regulation by Noradrenaline, Serotonin and ATP. Front. Integr. Neurosci. 9:70, 70 (2016).

    6. Marina, N., Ang, R., Machhada, A., et al. Brainstem hypoxia contributes to the development of hypertension in the spontaneously hypertensive rat. Hypertension 65(4), 775-783 (2015).