A selective inhibitor of FASN-TE
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ML-356

Item No. 20940

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-ethyl-N-[4-[4-(4-morpholinylsulfonyl)phenyl]-2-thiazolyl]-butanamide
CAS Number
1808260-45-8
Molecular Formula
C19H25N3O4S2
Formula Weight
423.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.09 mg/mlEthanol: 0.5 mg/ml
λmax
240, 292 nm
SMILES
O=S(C1=CC=C(C2=CSC(NC(C(CC)CC)=O)=N2)C=C1)(N3CCOCC3)=O
InChi Code
InChI=1S/C19H25N3O4S2/c1-3-14(4-2)18(23)21-19-20-17(13-27-19)15-5-7-16(8-6-15)28(24,25)22-9-11-26-12-10-22/h5-8,13-14H,3-4,9-12H2,1-2H3,(H,20,21,23)
InChi Key
YKNITTNJEATJKT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    10 mg

    $598

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    Product Description

    ML-356 is an inhibitor of the thioesterase domain of fatty acid synthase (FASN-TE; IC50 = 334 nM).1 It is selective for FASN over a number of other human thioesterases expressed in tumor cells, and selective for FASN-TE over its most closely related human homolog, ACOT4.1 In cells, ML-356 has been shown to block the biosynthesis of palmitate, the end product of FASN.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ardecky, R., Hedrick, M.P., Gosalia, P., et al. Selective inhibitors of FAS-TE. Probe Reports from the NIH Molecular Libraries Program (2010).