An antispasmodic
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Drotaverine (hydrochloride)

Item No. 20944

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(3,4-diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydro-isoquinoline, monohydrochloride
CAS Number
985-12-6
Molecular Formula
C24H31NO4 • HCl
Formula Weight
434.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMF:PBS (pH 7.2) (1:5): 0.16 mg/mlDMSO: 1 mg/mlEthanol: 0.5 mg/ml
λmax
244, 305, 359 nm
SMILES
CCOC1=C(OCC)C=C(CCN/C2=C\C3=CC=C(OCC)C(OCC)=C3)C2=C1.Cl
InChi Code
InChI=1S/C24H31NO4.ClH/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20;/h9-10,13-16,25H,5-8,11-12H2,1-4H3;1H/b20-13-;
InChi Key
JBFLYOLJRKJYNV-MASIZSFYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $76

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    50 mg

    $285

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    100 mg

    $494

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    500 mg

    $950

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    Product Description

    Drotaverine is an alkaloid that has been described as an inhibitor of phosphodiesterase 4 and negative allosteric modulator of L-type Ca2+ channels.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kapui, Z., Bence, J., Boronkay, E., et al. Behavioural effects of selective PDE4 inhibitors in relation to inhibition of catalytic activity and competition for [3H]rolipram binding. Neurobiology (Bp) 7(1), 71-73 (1999).

    2. Tömösközi, Z., Finance, O., and Arányi, P. Drotaverine interacts with the L-type Ca2+ channel in pregnant rat uterine membranes. Eur. J. Pharmacol. 449(1-2), 55-60 (2002).