An aromatase inhibitor
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Aminoglutethimide

Item No. 20947

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(4-aminophenyl)-3-ethyl-2,6-piperidinedione
CAS Number
125-84-8
Synonyms
  • DL-Aminoglutethimide
  • NSC 330915
Molecular Formula
C13H16N2O2
Formula Weight
232.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 10 mg/ml
λmax
242 nm
SMILES
O=C1NC(C(C2=CC=C(N)C=C2)(CC)CC1)=O
InChi Code
InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)
InChi Key
ROBVIMPUHSLWNV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    10 g

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    Cayman Chemical
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    Product Description

    Aminoglutethimide is an aromatase inhibitor (IC50 = 7.5 µM).1 Aromatase inhibitors, including aminoglutethimide, inhibit estrogen synthesis via aromatase, suppressing estrogen levels in post-menopausal women. Formulations containing aromatase inhibitors have been used to treat estrogen receptor-positive breast cancer in post-menopausal women.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Campbell, D.R., and Kurzer, M.S. Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. J. Steroid Biochem. Mol. Biol. 46(3), 381-388 (1993).

    2. Santen, R.J., and Harvey, H.A. Use of aromatase inhibitors in breast carcinoma. Endocr. Relat. Cancer 6, 75-92 (1999).

    3. Smith, I.E., and Dowsett, M. Aromatase inhibitors in breast cancer. N. Engl. J. Med. 348(24), 2431-2442 (2003).