A suppressor of IQ electron leak
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S1QEL1.1

Item No. 20982

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1-(3-acetamidophenyl)-N2-(2-(4-methyl-2-(p-tolyl)thiazol-5-yl)ethyl)oxalamide
CAS Number
897613-29-5
Synonyms
  • S1QEL
Molecular Formula
C23H24N4O3S
Formula Weight
436.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMF:PBS (pH 7.2) (1:2): 0.33 mg/mlDMSO: 2 mg/ml
λmax
240, 299 nm
SMILES
CC(NC1=CC=CC(NC(C(NCCC2=C(C)N=C(C3=CC=C(C)C=C3)S2)=O)=O)=C1)=O
InChi Code
InChI=1S/C23H24N4O3S/c1-14-7-9-17(10-8-14)23-25-15(2)20(31-23)11-12-24-21(29)22(30)27-19-6-4-5-18(13-19)26-16(3)28/h4-10,13H,11-12H2,1-3H3,(H,24,29)(H,26,28)(H,27,30)
InChi Key
BFNBJUBXXJKBFN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $28

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    1 mg

    $39

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    5 mg

    $125

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    10 mg

    $193

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    Product Description

    S1QEL1.1 is a small molecule that suppresses superoxide production during reverse electron transport through the IQ site of the mitochondrial respiratory complex I (IC50 = 70 nM) without affecting oxidative phosphorylation.1 It diminishes endogenous oxidative damage in primary astrocytes, reduces stress-induced signaling in a cardiomyocyte cell model, and protects against ischemia-reperfusion injury in perfused mouse heart.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brand, M.D., Goncalves, R.L.S., Orr, A.L., et al. Suppressors of superoxide-H2O2 production at site IQ of mitochondrial complex I protect against stem cell hyperplasia and ischemia-reperfusion injury. Cell Metab. 24(4), 582-592 (2016).