An inhibitor of the Bcl-2 family proteins
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TW-37

Item No. 20999

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[[2-(1,1-dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]-benzamide
CAS Number
877877-35-5
Molecular Formula
C33H35NO6S
Formula Weight
573.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH7.2) (1:2): 0.33 mg/mlDMSO: 15 mg/mlEthanol: 0.2 mg/ml
λmax
303 nm
SMILES
CC(C)(C)C1=C(S(C2=CC=C(NC(C3=C(O)C(O)=C(O)C(CC4=CC=CC=C4C(C)C)=C3)=O)C=C2)(=O)=O)C=CC=C1
InChi Code
InChI=1S/C33H35NO6S/c1-20(2)25-11-7-6-10-21(25)18-22-19-26(30(36)31(37)29(22)35)32(38)34-23-14-16-24(17-15-23)41(39,40)28-13-9-8-12-27(28)33(3,4)5/h6-17,19-20,35-37H,18H2,1-5H3,(H,34,38)
InChi Key
PQAPVTKIEGUPRN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $121

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    10 mg

    $204

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    25 mg

    $418

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    50 mg

    $713

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    Cayman Chemical
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    Product Description

    TW-37 is an inhibitor of the Bcl-2 family proteins Bcl-2, Mcl-1, and Bcl-xL (Kis = 120, 260, and 1,100 nM, respectively).1,2 It induces apoptosis, inhibits migration and capillary sprouting, and blocks the expression of the angiogenic chemokines CXCL1 and CXCL8 in endothelial cells.2 TW-37 decreases the density of functional human microvessels in the severe combined immunodeficient mouse model of human angiogenesis when administered intravenously.2 It has apoptotic action against leukemia, lymphoma, and pancreatic cancer cells.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Verhaegen, M., Bauer, J.A., de la Vega, C.M., et al. A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species. Cancer Res. 66(23), 11348-11359 (2006).

    2. Zeitlin, B.D., Joo, E., Dong, Z., et al. Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2. Cancer Res. 66(17), 8698-8706 (2006).

    3. Azmi, A.S., and Mohammad, R.M. Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy. J. Cell Physiol. 218(1), 13-21 (2009).