A selective adenosine A3 receptor agonist
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HEMADO

Item No. 21015

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(1-hexyn-1-yl)-N-methyl-adenosine
CAS Number
403842-38-6
Molecular Formula
C17H23N5O4
Formula Weight
361.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 20 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
236, 274, 298 nm
SMILES
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C(NC)N=C(C#CCCCC)N=C32)O[C@@H]1CO
InChi Code
InChI=1S/C17H23N5O4/c1-3-4-5-6-7-11-20-15(18-2)12-16(21-11)22(9-19-12)17-14(25)13(24)10(8-23)26-17/h9-10,13-14,17,23-25H,3-5,8H2,1-2H3,(H,18,20,21)/t10-,13-,14-,17-/m1/s1
InChi Key
KOCIMZNSNPOGOP-IWCJZZDYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $65

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    5 mg

    $309

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    10 mg

    $520

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    Product Description

    HEMADO is a selective agonist of the adenosine A3 receptor (Kis = 1.1, 327, and 1,230 nM for A3, A1, and A2A receptors, respectively).1 HEMADO reduces release of lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB) from myocardium in isolated rat hearts subjected to ischemia-reperfusion injury.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Volpini, R., Costanzi, S., Lambertucci, C., et al. N6-Alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A3 receptor and a starting point for searching A2B ligands. J. Med. Chem. 45(15), 3271-3279 (2002).

    2. Amani, M., Jeddi, S., Ahmadiasl, N., et al. Effect of HEMADO on level of CK-MB and LDH enzymes after ischemia/reperfusion injury in isolated rat heart. Bioimpacts 3(2), 101-104 (2013).