A positive allosteric modulator of α7-containing nAChRs
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NS 1738

Item No. 21018

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]-urea
CAS Number
501684-93-1
Synonyms
  • NSC 213859
Molecular Formula
C14H9Cl2F3N2O2
Formula Weight
365.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 10 mg/ml
λmax
209, 263, 296 nm
SMILES
ClC1=C(C=C(C=C1)C(F)(F)F)NC(NC2=C(C=CC(Cl)=C2)O)=O
InChi Code
InChI=1S/C14H9Cl2F3N2O2/c15-8-2-4-12(22)11(6-8)21-13(23)20-10-5-7(14(17,18)19)1-3-9(10)16/h1-6,22H,(H2,20,21,23)
InChi Key
OUDXRNQPVSMGDW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    Product Description

    NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs).1 When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through α7-containing nAChRs (EC50 = 3.4 µM).1 NS 1738 displays no substantial activity for α4β2-, α3β3-, and α1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats.1 NS 1738 also improves performance in the rat social recognition test.1 NS 1738 is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Timmermann, D.B., Gronlien, J.H., Kohlhaas, K.L., et al. An allosteric modulator of the α7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. JPET 323(1), 294-307 (2007).

    2. Cheng, Q., and Yakel, J.L. Presynaptic α7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activation. J. Neurosci. 34(1), 124-133 (2014).

    3. Freitas, K., Carroll, F.I., and Damaj, M.I. The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models. J. Pharmacol. Exp. Ther. 344(1), 264-275 (2013).