A TRPA1 channel activator
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Supercinnamaldehyde

Item No. 21019

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-dihydro-1-methyl-3-(2-oxopropylidene)-2H-indol-2-one
CAS Number
70351-51-8
Molecular Formula
C12H11NO2
Formula Weight
201.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 2 mg/ml
λmax
260, 324 nm
SMILES
CN(C1=CC=CC=C1/C2=C/C(C)=O)C2=O
InChi Code
InChI=1S/C12H11NO2/c1-8(14)7-10-9-5-3-4-6-11(9)13(2)12(10)15/h3-7H,1-2H3/b10-7-
InChi Key
CZKBLHCEDVWPRN-YFHOEESVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    1 mg

    $35

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    5 mg

    $106

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    10 mg

    $195

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    Product Description

    Supercinnamaldehyde is an activator of the transient receptor potential ankyrin 1 (TRPA1) channel (EC50 = 0.8 µM) and an analog of cinnamaldehyde.1 TRPA1 is a nociceptor expressed on sensory neurons and is activated by hot and cold temperatures, mechanical stimuli, and pain.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Macpherson, L.J., Dubin, A.E., Evans, M.J., et al. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445(7127), 541-545 (2007).

    2. Baraldi, P.G., Preti, D., Materazzi, S., et al. Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J. Med. Chem. 53(14), 5085-5107 (2010).