2-PMAP

2-PMAP is an inhibitor of the production of amyloid precursor protein (APP) and amyloid-β (Aβ) secretion.¹ It reduces levels of APP and its intracellular C-terminal fragments α-CTF and β-CTF in CHO APP751SW cells when used at a concentration of 10 μM. 2-PMAP also reduces secretion of Aβ (1-40) and Aβ (1-42) by 88.6 and 84.9%, respectively, in CHO APP751SW cells when used at a concentration of 50 μM without inducing cellular toxicity. In vivo, 2-PMAP reduces brain levels of full-length APP, α-CTF and β-CTF, and soluble Aβ (1-40) and Aβ (1-42) in the APP_SWPS1_dE9 transgenic mouse model of Alzheimer's disease. It also improves novel object memory as well as spatial memory in the radial arm maze in APP_SWPS1_dE9 transgenic mice.

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1. Asuni, A.A., Guridi, M., Pankiewicz, J.E., et al. Modulation of APP expression reduces Aβ deposition in a mouse model. Ann. Neurol. 75(5), 684-699 (2014).