An antitumor prodrug
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CB-1954

Item No. 21023

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(1-aziridinyl)-2,4-dinitro-benzamide
CAS Number
21919-05-1
Synonyms
  • NSC 115829
  • Tretazicar
Molecular Formula
C9H8N4O5
Formula Weight
252.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
223, 269, 328 nm
SMILES
O=C(N)C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C(N2CC2)=C1
InChi Code
InChI=1S/C9H8N4O5/c10-9(14)5-3-7(11-1-2-11)8(13(17)18)4-6(5)12(15)16/h3-4H,1-2H2,(H2,10,14)
InChi Key
WOCXQMCIOTUMJV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

    $253

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    Cayman Chemical
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    Product Description

    CB-1954 is a prodrug that is enzymatically activated to generate an antitumor agent that forms DNA-DNA interstrand crosslinks.1 In rat Walker 256 carcinoma cells, CB-1954 is reduced by NAD(P)H:quinone oxidoreductase (NQO1) to the cytotoxic derivative 5-(aziridin-1-yl)-4-hydroxylamineo 2 nitrobenzamide, a bifunctional alkylating agent.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Knox, R.J., Jenkins, T.C., Hobbs, S.M., et al. Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy. Cancer Res. 60(15), 4179-4186 (2000).