An analog of ubiquinone (coenzyme Q10)
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Decylubiquinone

Item No. 21027

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-decyl-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
CAS Number
55486-00-5
Molecular Formula
C19H30O4
Formula Weight
322.4
Purity
≥98%
Formulation (Request formulation change)
A 25 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 15 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.3 mg/ml
λmax
277, 403 nm
SMILES
COC(C(C(CCCCCCCCCC)=C1C)=O)=C(OC)C1=O
InChi Code
InChI=1S/C19H30O4/c1-5-6-7-8-9-10-11-12-13-15-14(2)16(20)18(22-3)19(23-4)17(15)21/h5-13H2,1-4H3
InChi Key
VMEGFMNVSYVVOM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $43

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    10 mg

    $61

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    25 mg

    $140

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    50 mg

    $237

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    Product Description

    Decylubiquinone is an analog of ubiquinone (coenzyme Q10; Item No. 11506). It blocks reactive oxygen species production in response to glutathione depletion and inhibits activation of the mitochondrial permeability transition.1 Decylubiquinone inhibited opening of the mitochondrial permeability transition pore in response to calcium overload in rat liver mitochondria in different cell lines at concentrations between 50-100 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Armstrong, J.S., Whiteman, M., Rose, P., et al. The Coenzyme Q10 analog decylubiquinone inhibits the redox-activated mitochondrial permeability transition: Role of mitochondrial complex III. The Journal of Biological Chemisty 278(49), 49079-49084 (2003).

    2. Devun, F., Walter, L., Belliere, J., et al. Ubiquinone analogs: A mitochondrial permeability transition pore-dependent pathway to selective cell death. PLoS One 5(7), (2010).