A nonpeptidic HIV protease inhibitor
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Labeled Version(s)
28907Tipranavir-d4
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Tipranavir

Item No. 21028

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-[(1R)-1-[(6R)-5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide
CAS Number
174484-41-4
Synonyms
  • PNU-140690
Molecular Formula
C31H33F3N2O5S
Formula Weight
602.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleChloroform: slightly solubleMethanol: slightly solubleMethanol: slightly soluble
λmax
254 nm
SMILES
O=S(C1=NC=C(C(F)(F)F)C=C1)(NC2=CC([C@H](C3=C(O)C[C@@](CCC)(CCC4=CC=CC=C4)OC3=O)CC)=CC=C2)=O
InChi Code
InChI=1S/C31H33F3N2O5S/c1-3-16-30(17-15-21-9-6-5-7-10-21)19-26(37)28(29(38)41-30)25(4-2)22-11-8-12-24(18-22)36-42(39,40)27-14-13-23(20-35-27)31(32,33)34/h5-14,18,20,25,36-37H,3-4,15-17,19H2,1-2H3/t25-,30-/m1/s1
InChi Key
SUJUHGSWHZTSEU-FYBSXPHGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Tipranavir is a potent, orally bioavailable nonpeptidic HIV aspartyl protease inhibitor (Ki = < 1 nM) that prevents cleavage and thus activation of functional HIV cleaved proteins.1,2 Formulations containing tipranavir, in combination with other HIV treatments, are effective against multidrug resistant viruses and are used in the treatment of HIV infection progression in patients who have not responded well to initial treatments.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Turner, S.R., Strohbach, J.W., Tommasi, R.A., et al. Tipranavir (PNU-140690): A potent, orally bioavailable nonpeptidic HIV protease inhibitor of the 5,6-dihydro-4-hydroxy-2-pyrone sulfonamide class. J. Med. Chem. 41(18), 3467-3476 (1998).

    2. Thaisrivongs, S., and Strohbach, J.W. Structure-based discovery of Tipranavir disodium (PNU-140690E): A potent, orally bioavailable, nonpeptidic HIV protease inhibitor. Biopoly. 51(1), 51-58 (1999).

    3. Llibre, J.M., Schapiro, J.M., and Clotet, B. Clinical implications of genotypic resistance to the newer antiretroviral drugs in HIV-1-infected patients with virological failure. Clin. Infect. Dis. 50(6), 872-881 (2010).