A mitochondrial F1FO-ATPase inhibitor
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BTB06584

Item No. 21032

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-chloro-benzoic acid, 2-nitro-5-(phenylsulfonyl)phenyl ester
CAS Number
219793-45-0
Synonyms
  • BTB
Molecular Formula
C19H12ClNO6S
Formula Weight
417.8
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH7.2) (1:2): 0.33 mg/mlDMSO: 20 mg/ml
λmax
248 nm
SMILES
O=S(C1=CC(OC(C2=CC=C(Cl)C=C2)=O)=C([N+]([O-])=O)C=C1)(C3=CC=CC=C3)=O
InChi Code
InChI=1S/C19H12ClNO6S/c20-14-8-6-13(7-9-14)19(22)27-18-12-16(10-11-17(18)21(23)24)28(25,26)15-4-2-1-3-5-15/h1-12H
InChi Key
WNDWKKPBLAKXMI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $90

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    10 mg

    $124

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    25 mg

    $219

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    50 mg

    $392

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    Product Description

    BTB06584 (BTB) is an inhibitor of mitochondrial F1FO-ATP synthase (F1FO-ATPase) that has no effect on mitochondrial membrane potential (ΔΨm) or oxygen consumption.1 It slows ATP consumption following inhibition of cellular respiration. BTB (100 μM) protects against ischemic cell death of HL-1 cells and rescues defective hemoglobin synthesis in pinotage (pnt) mutant zebrafish. BTB, in combination with ionizing radiation, increases apoptosis of A549 cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ivanes, F., Faccenda, D., Gatliff, J., et al. The compound BTB06584 is an IF1-dependent selective inhibitor of the mitochondrial F1 Fo-ATPase. Br. J. Pharmacol. 171(18), 4193-4206 (2014).

    2. Wang, Y., Hou, Q., Xiao, G., et al. Selective ATP hydrolysis inhibition in F1Fo ATP synthase enhances radiosensitivity in non-small-cell lung cancer cells (A549). Oncotarget (2017).