An antitubercular agent
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DprE1-IN-2

Item No. 21034

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[[6-(dimethylamino)-5-methyl-4-pyrimidinyl]methyl]-N-(2-hydroxyethyl)-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide
CAS Number
1615713-87-5
Molecular Formula
C19H24N6O2
Formula Weight
368.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2mg/mLDMSO: 2mg/mLDMSO:PBS (pH 7.2) (1:4): 0.2mg/mL
λmax
214, 253, 294 nm
SMILES
CC1=CN=C2C(N(CC3=C(C)C(N(C)C)=NC=N3)C=C2C(NCCO)=O)=C1
InChi Code
InChI=1S/C19H24N6O2/c1-12-7-16-17(21-8-12)14(19(27)20-5-6-26)9-25(16)10-15-13(2)18(24(3)4)23-11-22-15/h7-9,11,26H,5-6,10H2,1-4H3,(H,20,27)
InChi Key
BLNAAWXUNQHVNT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    DprE1-IN-2 is an antitubercular agent that is active against M. tuberculosis in vitro, with MIC values ranging from 0.5 to 1.56 μM.1 It is an inhibitor of decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1; IC50 = 32 nM), an enzyme involved in mycobacterial cell wall biogenesis. DrpE1-IN-2 (300 mg/kg) reduces lung bacterial burden in a mouse model of chronic tuberculosis infection and exhibits a synergistic effect when administered in combination with TMC207 (Item No. 20247).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chatterji, M., Shandil, R., Manjunatha, M.R., et al. 1,4-azaindole, a potential drug candidate for treatment of tuberculosis. Antimicrob. Agents Chemother. 58(9), 5325-5331 (2014).