A RAD51 activator
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Product Type

Small Molecule Modulators
Small Molecule Activators

Research Area

RS-1

Item No. 21037

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]-benzamide
CAS Number
312756-74-4
Molecular Formula
C20H16Br2N2O3S
Formula Weight
524.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 20 mg/ml
λmax
281 nm
SMILES
BrC1=CC=C(NC(C2=CC=C(Br)C(S(NCC3=CC=CC=C3)(=O)=O)=C2)=O)C=C1
InChi Code
InChI=1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25)
InChi Key
SWKAVEUTKGKHSR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $63

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    25 mg

    $145

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    50 mg

    $203

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    Product Description

    RS-1 is an activator of DNA repair protein RAD51 (Kd = 48-107 for human RAD51 with different cofactors present).1 It stimulates homologous strand assimilation activity at least 5- to 11-old, enhancing homologous recombination activity of hRAD51.1 RS-1 is a potent enhancer of CRISPR-mediated genome editing, increasing homology directed repair 3- to 6-fold.2 It is used to increase CRISPR-mediated knock-in efficiencies in vitro and in vivo.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jayathilaka, K., Sheridan, S.D., Bold, T.D., et al. A chemical compound that stimulates the human homologous recombination protein RAD51. Proc. Natl. Acad. Sci. USA 105(41), 15848-15853 (2008).

    2. Pinder, J., Salsman, J., and Dellaire, G. Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing. Nucleic Acids Res. 43(19), 9379-9392 (2015).

    3. Pan, Y., SHen, N., Jung-Klawitter, S., et al. CRISPR RNA-guided FokI nucleases repair a PAH variant in a phenylketonuria model. Sci. Rep. 6, 65794 (2016).

    4. Song, J., Yang, D., Xu, J., et al. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency. Nat. Commun. 7, 10548 (2016).