The oxidized form of NADPH
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Alternative(s)
10004675NADP+ (sodium salt hydrate)
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NADP+ (hydrate)

Item No. 21045

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'→5'-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium, inner salt, hydrate
Synonyms
  • Coenzyme II
  • β-NADP
  • Nicotinamide adenine dinucleotide phosphate
  • TPN
Molecular Formula
C21H28N7O17P3 • XH2O
Formula Weight
743.4
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
258 nm
SMILES
O[C@H]1[C@@H](OP(O)(O)=O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H]([N+]5=CC(C(N)=O)=CC=C5)O4)([O-])=O)(O)=O
InChi Code
InChI=1S/C21H28N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
InChi Key
XJLXINKUBYWONI-NNYOXOHSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $38

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    250 mg

    $74

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    500 mg

    $129

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    1 g

    $238

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    Product Description

    NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate (NADPH, Item No. 9000743). It serves as a cofactor in various biological reactions.1,2 In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status, and intracellular signaling.2,3 For example, binding of NADP+ to β-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation.4 NADP+ is biosynthesized from NAD+ (Item No. 16077) by NAD kinase, with ATP as the phosphoryl donor.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jackson, J.B. A review of the binding-change mechanism for proton-translocating transhydrogenase. Biochim. Biophys. Acta 1817(10), 1839-1846 (2012).

    2. Nakamura, M., Bhatnagar, A., and Sadoshima, J. Overview of pyridine nucleotides review series. Circ. Res. 111(5), 604-610 (2012).

    3. Ziegler, M. A vital link between energy and signal transduction: Regulatory functions of NAD(P). FEBS J. 272(18), 4561-4564 (2014).

    4. Kilfoil, P.J., Tipparaju, S.M., Barski, O.A., et al. Regulation of ion channels by pyridine nucleotides. Circ. Res. 112(4), 721-741 (2013).

    5. Shi, F., Li, Y., Li, Y., et al. Molecular properties, functions, and potential applications of NAD kinases. Acta Biochim. Biophys. Sin. (Shanghai) 41(5), 352-361 (2009).